💊The 10 Most Common SSRI Side Effects

Selective Serotonin Reuptake Inhibitors (SSRIs) are some of the most prescribed medications in the world. They can be life- changing for people struggling with depression and anxiety, but like any medication, they come with potential side effects.

From fatigue to insomnia, here's a breakdown of the 10 most common SSRI side effects, why they happen, and what you can do about them.

1. 🤢 Nausea

When serotonin levels rise, your digestive tract (which actually houses most of your body’s serotonin receptors) can become overstimulated. This often leads to mild nausea, upset stomach, or occasional vomiting during the first few weeks.
 

What helps: Taking the medication with food and staying hydrated usually eases symptoms.

2. 😴 Drowsiness or fatigue

Some people find that SSRIs make them feel sluggish, foggy, or tired. This is due to serotonin’s role in sleep and energy regulation.

What helps: Taking your dose at night and maintaining a regular sleep schedule can reduce daytime fatigue.

3. 🌙 Insomnia

On the flip side, SSRIs can sometimes cause restlessness and trouble falling asleep, particularly medications with stimulating effects like fluoxetine (Prozac).

 

What helps: Morning dosing, limiting caffeine, and using relaxation techniques before bed can improve sleep quality.

4. 🤕 Headaches

SSRIs can cause tension-type or migraine-like headaches as your brain adjusts to new serotonin levels and changes in blood vessel activity.

What helps: Over-the-counter pain relief, rest, and consistent hydration typically help until your body adapts.