Peyronie's disease is a condition in which fibrous scar tissue develops inside the penis, causing curved and sometimes painful erections. This male condition is thought to be caused by trauma or injury to the penis, such as a blow to the groin when playing contact sports.

Peyronie's disease affects an estimated 3 to 9 percent of men worldwide and can lead to complications, including erectile dysfunction (ED) and reduced quality of life, according to a 2019 study published in Therapeutic Advances in Urology.

The following treatments for Peyronie's disease can reduce penile curvature and related pain, and successfully restore sexual function.


Xiaflex is the only medication approved by the Food and Drug Administration for the treatment of Peyronie's disease. The active ingredient in Xiaflex is collagenase clostridium