If you have a penis, your chances of getting diagnosed with penile cancer are low. Penile cancer accounts for less than 1 percent of cancers in men in the United States. However, the risk of developing penile cancer can increase with human papillomavirus (HPV) infection. An estimated 63 percent of penile cancer cases are attributable to HPV each year, according to the Centers for Disease Control and Prevention (CDC).
HPV is a common sexually transmitted infection (STI). Most men who get HPV won't go on to develop cancer, but there isn't a clear number associated with how much your risk of penile cancer increases if you've had the infection. S. Adam Ramin, M.D., a urologist and the medical director of Urology Cancer Specialists in Los Angeles, estimates it's only about a 5 percent increased risk.
However, the tricky thing with HPV is many people can be infected with the virus and not even realize it. In fact, the CDC notes